Linking retinal amyloid imaging to cognition and hippocampal integrity – a retrospective cohort analysis
Our pilot study provides preliminary evidence that perivascular Aβ accumulation in smaller vessels of the superotemporal retina may be a marker of memory impairment that may interact synergistically with hippocampal atrophy. Longitudinal studies consisting of multimodal ophthalmic assessments, brain imaging, ADRD biofluid markers, and cognitive testing will be necessary to capture the temporal sequence of retinal pathological changes and their associations with those in the brain.
Authors
- Jonah Doustar (ORCID: https://orcid.org/0000-0002-3029-0067)
- Dieu‐Trang Fuchs
- Sarah Kremen (ORCID: https://orcid.org/0000-0003-2593-0602)
- Nancy L. Sicotte (ORCID: https://orcid.org/0000-0002-5131-3352)
- Maya Koronyo‐Hamaoui (ORCID: https://orcid.org/0000-0003-2864-8442)
- Patrick D. Lyden (ORCID: https://orcid.org/0000-0001-6170-4042)
- Dale Sherman
- Oana M. Dumitrascu (ORCID: https://orcid.org/0000-0003-2033-449X)
- Keith L Black
- Yosef Koronyo
- Mitzi M. Gonzales
Institutions
- University of Southern California (US)
- Cedars-Sinai Medical Center (US)
- Mayo Clinic in Arizona (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_102028
- Primary Topic
- Retinal Imaging and Analysis
- Type
- article
- Field-Weighted Citation Impact
- 0.00