Patients with persistent atrial fibrillation and metabolic comorbidities have an altered inflammatory state of atrial epicardial adipose tissue, which is linked to CT-attenuation
Patients with persistent versus paroxysmal AF exhibited increased EAT neutrophils, which is reflected by CT-EAT-attenuation. Those with AF recurrence, hypertension and diabetes had adipocyte hypertrophy which may imply a common mechanism underlying these conditions.
Authors
- Etto C. Eringa (ORCID: https://orcid.org/0000-0002-9814-5149)
- Robin Wesselink (ORCID: https://orcid.org/0000-0001-5671-2531)
- Eva R. Meulendijks (ORCID: https://orcid.org/0000-0002-8071-303X)
- Benedetta Fabrizi
- Ron A. Hoebe (ORCID: https://orcid.org/0000-0002-1553-4342)
- Auriane C. Ernault (ORCID: https://orcid.org/0000-0002-5909-4991)
- Steffen Bruns (ORCID: https://orcid.org/0000-0002-5607-2770)
- Joris R. de Groot (ORCID: https://orcid.org/0000-0002-8122-7017)
- Tim A. C. de Vries
- Ivana Išgum (ORCID: https://orcid.org/0000-0003-1869-5034)
- Pietro Zappala (ORCID: https://orcid.org/0009-0002-9051-1201)
- Damini Dey
- Wim J. P. van Boven
- Rushd F. M. Al-Shama
- H. W. M. Niessen
- Antoine H. G. Driessen
- Thomas van den Boogert
- Sébastien P. J. Krul
- I. Zbairi
- R. Nils Planken
Institutions
- Cedars-Sinai Medical Center (US)
- Rijksmuseum (NL)
- Mayo Clinic (US)
- Maastricht University (NL)
- Amsterdam Neuroscience (NL)
- Isala (NL)
- Amsterdam University Medical Centers (NL)
- Rijnstate Hospital (NL)
- University of Amsterdam (NL)
Publication Details
- Journal
- Cardiovascular Diabetology
- Published
- 2025-12-26
- DOI
- https://doi.org/10.1186/s12933-025-02985-1
- Citations
- 1
- Primary Topic
- Cardiovascular Disease and Adiposity
- Type
- article
- Field-Weighted Citation Impact
- 1.39