In silico identification of HDAC3 inhibitors for potential Alzheimer’s disease therapeutics
The study identified novel compounds with HDAC3 inhibition. However, it also highlighted the need for further structural optimisation to improve inhibitory activity, maintain selectivity, ensure BBB permeability and reduce toxicity.
Authors
- Jacques Joubert (ORCID: https://orcid.org/0000-0003-0378-7091)
- Erika Kapp (ORCID: https://orcid.org/0000-0001-5747-4766)
- Thabo Makgoba
Institutions
- University of the Western Cape (ZA)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70859_104774
- Primary Topic
- Histone Deacetylase Inhibitors Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00