Targeting SEMA4D/PLXN signaling through reactive glia as a common pathology for the treatment of neurodegenerative disorders

Given the many physiological parallels between glial activation and inflammatory processes in HD and AD, results from these studies suggest that preventing astrocyte activation and reducing brain inflammation and associated vascular disruption with pepinemab treatment could be an attractive alternative or complement to anti-Aβ antibodies and support the broad application of glial regulators to treat cognitive dysfunction and neurodegenerative disease.

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Publication Details

Journal
Alzheimer s & Dementia
Published
2025-12-01
DOI
https://doi.org/10.1002/alz70859_103679
Primary Topic
Axon Guidance and Neuronal Signaling
Type
article
Field-Weighted Citation Impact
0.00
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article

Targeting SEMA4D/PLXN signaling through reactive glia as a common pathology for the treatment of neurodegenerative disorders

Elizabeth E. Evans, Leslie Balch, Terrence Lee Fisher, Amber Foster et al.
Alzheimer s & Dementia
Axon Guidance and Neuronal Signaling
article

Targeting SEMA4D/PLXN signaling through reactive glia as a common pathology for the treatment of neurodegenerative disorders

Elizabeth E. Evans, Leslie Balch, Terrence Lee Fisher, Amber Foster, Maurice Zauderer, Andrew Feigin, Alan Howell, Renee Kirk, Crystal L. Mallow, Anton P Porsteinsson, Vikas Mishra, Malgorzata Gil‐Moore, Elaine E Gersz
article en

Abstract

Given the many physiological parallels between glial activation and inflammatory processes in HD and AD, results from these studies suggest that preventing astrocyte activation and reducing brain inflammation and associated vascular disruption with pepinemab treatment could be an attractive alternative or complement to anti-Aβ antibodies and support the broad application of glial regulators to treat cognitive dysfunction and neurodegenerative disease.

Alzheimer s & DementiaVol. 21(S5)
NYU Langone Health (US), Alzheimer’s Disease Neuroimaging Initiative (US), Vaccinex (United States) (US)
Good health and well-being
Openalex Percentile: Top 37%
Axon Guidance and Neuronal Signaling
DOIOpen Access PDFOpenAlex
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Targeting SEMA4D/PLXN signaling through reactive glia as a common pathology for the treatment of neurodegenerative disorders — Elizabeth E. Evans, Leslie Balch, et al. · Alzheimer s & Dementia (2025) | TGRS Research Map | TGRS