Exploring the Genetic Correlation Between Memory Performance and Multimodal Neuroimaging Phenotypes
Genetic covariance analyses between memory and multimodal IDPs displayed wide-ranging significant results, with the most pronounced effects centered within medial temporal lobe and adjacent structures. These associations largely parallel AD brain vulnerability, particularly within regions associated with the default mode network. Furthermore, the identification of brain traits beyond the hippocampus as associated with the genetic architecture of memory suggests additional neural correlates to evaluate for future biomarker development.
Authors
- Timothy J. Hohman (ORCID: https://orcid.org/0000-0002-3377-7014)
- Emily H. Trittschuh (ORCID: https://orcid.org/0000-0003-0557-1542)
- Derek B. Archer (ORCID: https://orcid.org/0000-0001-8638-0785)
- Logan C. Dumitrescu (ORCID: https://orcid.org/0000-0002-9782-9944)
- Leslie S. Gaynor (ORCID: https://orcid.org/0000-0003-1121-4365)
- Brandon S. Klinedinst (ORCID: https://orcid.org/0000-0003-2697-1852)
- Seo‐Eun Choi (ORCID: https://orcid.org/0000-0002-2163-688X)
- Aditi Sathe
- Yisu Yang
- Elizabeth Sanders
- Kurt Schilling
- Paul K Crane
- Bennett A. Landman
- Michael L. Lee
Institutions
- Vanderbilt University (US)
- University of Washington (US)
- VA Puget Sound Health Care System (US)
- Vanderbilt University Medical Center (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_104003
- Primary Topic
- Functional Brain Connectivity Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00