Blood biomarkers of neuronal injury and glial cell dysfunction and 25‐year cognitive decline and incident dementia in the ARIC study
Blood biomarkers reflecting neuropathological processes, including microglial activation, astrocytic reactivity, and neuronal degeneration, were associated with faster cognitive decline and increased dementia risk, suggesting that they may aid in risk stratification and intervention strategies for ADRDs. Future analyses will examine whether these associations differ by race and APOE-ε4 status.
Authors
- Kevin Sullivan (ORCID: https://orcid.org/0000-0001-9147-0988)
- Xiaoqian Zhu (ORCID: https://orcid.org/0009-0007-7357-7985)
- Srishti Shrestha
- Priya Palta
- B Gwen Windham
- Thomas H. Mosley
- Sudha Seshadri
- Rebecca F. Gottesman
- Prashanthi Vemuri
- Michael E. Griswold
- Myriam Fornage
Institutions
- University of North Carolina at Chapel Hill (US)
- The University of Texas at San Antonio Health Science Center (US)
- Jackson Memorial Hospital (US)
- University of Mississippi Medical Center (US)
- National Institute of Neurological Disorders and Stroke (US)
- Institute for Neurodegenerative Disorders (US)
- Mayo Clinic in Arizona (US)
- Brown Foundation (US)
- The University of Texas Health Science Center at Houston (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_104381
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00