Combined metabolomic and metagenomic analysis reveals inflammatory bowel disease diversity in pediatric and adult patients
Functional metabolomics holds transformative potential for IBD diagnostics across all age groups, with especially significant implications for pediatric patients. The distinct metabolic and metagenetic profiles observed in the pediatric cohort may represent primary alterations in IBD, providing valuable insights for exploring novel mechanisms underlying disease pathogenesis.
Authors
- Irina V. Kolesnikova (ORCID: https://orcid.org/0000-0001-6608-6802)
- Daria I. Boldyreva (ORCID: https://orcid.org/0000-0003-2573-7634)
- Vladimir A. Veselovsky (ORCID: https://orcid.org/0000-0002-4336-9452)
- Evgenii I. Olekhnovich (ORCID: https://orcid.org/0000-0003-4899-342X)
- Olga Yu. Shagaleeva (ORCID: https://orcid.org/0009-0006-5946-483X)
- Marina A. Manina (ORCID: https://orcid.org/0000-0003-2560-6722)
- E. Yu. Lomakina (ORCID: https://orcid.org/0000-0002-7703-8328)
- Б. А. Ефимов (ORCID: https://orcid.org/0009-0003-8879-6516)
- Daria A. Kashatnikova
- Tatiana Grigoryeva
- Natalya B. Zakharzhevskaya (ORCID: https://orcid.org/0000-0003-1045-1895)
- Dmitry A. Kardonsky (ORCID: https://orcid.org/0000-0001-7231-3629)
- Anna Vanyushkina (ORCID: https://orcid.org/0000-0002-2538-689X)
- Maxim D. Morozov (ORCID: https://orcid.org/0000-0001-6128-0921)
- Ivan S. Samolygo (ORCID: https://orcid.org/0000-0002-8307-5168)
- Polina Y. Zoruk
- Polina Kondrashova
- Victoriia Kazakova
- Tatiana N Kalachnuk
- Elizaveta A Vorobyeva
- Elena A Belousova
- Artemiy A Silantyev
- Svetlana I Erdes
- Andrey V Chaplin
- Maria I Markelova
Institutions
- Skolkovo Institute of Science and Technology (RU)
- Pirogov Russian National Research Medical University (RU)
- Vavilov Institute of General Genetics (RU)
Publication Details
- Journal
- World Journal of Gastroenterology
- Published
- 2025-12-26
- DOI
- https://doi.org/10.3748/wjg.v31.i48.112653
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.00