Unveiling Cognitive Decline Through the Lens of Mild Behavioral Impairment: Longitudinal Insights from the Southeast Asia BIOCIS Study

Self-reported MBI-C scores predict early cognitive decline, reinforcing MBI symptoms as clinical markers. The strengthening association over time underscores their progressive impact on cognition. Notably, the Abnormal Beliefs subdomain showed the strongest association with cognitive deterioration, suggesting its utility as a marker for progression. Addressing MBI could mitigate cognitive decline, emphasizing its role in early intervention. Furthermore, the tendency in Southeast Asia to underreport behavioral symptoms may indicate that observed associations reflect more severe underlying pathology, reinforcing the robustness of these findings.