Using computational modeling to assess decision‐making processes in a prodromal rat model of Alzheimer’s disease
We show that DDM is a useful tool for revealing changes in cognitive function in a prodromal animal model of AD that were otherwise not evident using standard task metrics. Ultimately, by combining this computational approach with other biomarkers (e.g. molecular; neurophysiological), we can enhance our understanding of the earliest stages of disease progression and improve the translational potential of preclinical research.
Authors
- Shawn N. Whitehead (ORCID: https://orcid.org/0000-0003-4728-8067)
- Ashley L. Schormans (ORCID: https://orcid.org/0000-0003-3327-6591)
- Brian L. Allman (ORCID: https://orcid.org/0000-0001-8793-2019)
- Salonee V. Patel (ORCID: https://orcid.org/0000-0003-0148-728X)
- Mohammed U Al‐youzbaki
- Sarah H Hayes
Institutions
- Western University (CA)
- University of Rochester (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70859_105666
- Primary Topic
- Memory and Neural Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00