Using computational modeling to assess decision‐making processes in a prodromal rat model of Alzheimer’s disease

We show that DDM is a useful tool for revealing changes in cognitive function in a prodromal animal model of AD that were otherwise not evident using standard task metrics. Ultimately, by combining this computational approach with other biomarkers (e.g. molecular; neurophysiological), we can enhance our understanding of the earliest stages of disease progression and improve the translational potential of preclinical research.

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Publication Details

Journal
Alzheimer s & Dementia
Published
2025-12-01
DOI
https://doi.org/10.1002/alz70859_105666
Primary Topic
Memory and Neural Mechanisms
Type
article
Field-Weighted Citation Impact
0.00
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article

Using computational modeling to assess decision‐making processes in a prodromal rat model of Alzheimer’s disease

Shawn N. Whitehead, Ashley L. Schormans, Brian L. Allman, Salonee V. Patel et al.
Alzheimer s & Dementia
Memory and Neural Mechanisms
article

Using computational modeling to assess decision‐making processes in a prodromal rat model of Alzheimer’s disease

Shawn N. Whitehead, Ashley L. Schormans, Brian L. Allman, Salonee V. Patel, Mohammed U Al‐youzbaki, Sarah H Hayes
article en

Abstract

We show that DDM is a useful tool for revealing changes in cognitive function in a prodromal animal model of AD that were otherwise not evident using standard task metrics. Ultimately, by combining this computational approach with other biomarkers (e.g. molecular; neurophysiological), we can enhance our understanding of the earliest stages of disease progression and improve the translational potential of preclinical research.

Alzheimer s & DementiaVol. 21(S5)
Western University (CA), University of Rochester (US)
Gender equality
Openalex Percentile: Top 32%
Memory and Neural Mechanisms
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Using computational modeling to assess decision‐making processes in a prodromal rat model of Alzheimer’s disease — Shawn N. Whitehead, Ashley L. Schormans, et al. · Alzheimer s & Dementia (2025) | TGRS Research Map | TGRS