397P Modulating tumor mechanics and vascular barriers to enhance chemotherapy efficacy in pancreatic tumors and melanoma

Pancreatic ductal adenocarcinoma (PDAC) is characterized by dense stroma and dysfunctional vasculature, limiting drug delivery and immune infiltration. Melanoma, though less fibrotic, remains highly metastatic and treatment-resistant. To overcome these barriers, we repurposed the antihistamine ketotifen with ultrasound-mediated sonopermeation to normalize the tumor microenvironment (TME) and enhance chemotherapy efficacy in murine PDAC and melanoma models.

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Publication Details

Journal
Immuno-Oncology Technology
Published
2025-12-01
DOI
https://doi.org/10.1016/j.iotech.2025.101394
Primary Topic
Ultrasound and Hyperthermia Applications
Type
article
Field-Weighted Citation Impact
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article

397P Modulating tumor mechanics and vascular barriers to enhance chemotherapy efficacy in pancreatic tumors and melanoma

C. Voutouri, A. Charalambous, S. Angeli, C. Neophytou et al.
Immuno-Oncology Technology
Ultrasound and Hyperthermia Applications
article

397P Modulating tumor mechanics and vascular barriers to enhance chemotherapy efficacy in pancreatic tumors and melanoma

C. Voutouri, A. Charalambous, S. Angeli, C. Neophytou, F. Mpekris, T. Stylianopoulos
article en

Abstract

Pancreatic ductal adenocarcinoma (PDAC) is characterized by dense stroma and dysfunctional vasculature, limiting drug delivery and immune infiltration. Melanoma, though less fibrotic, remains highly metastatic and treatment-resistant. To overcome these barriers, we repurposed the antihistamine ketotifen with ultrasound-mediated sonopermeation to normalize the tumor microenvironment (TME) and enhance chemotherapy efficacy in murine PDAC and melanoma models.

Immuno-Oncology TechnologyVol. 28
University of Cyprus (CY), Cyprus Institute of Neurology and Genetics (CY)
Good health and well-being
Openalex Percentile: Top 42%
Ultrasound and Hyperthermia Applications
DOIOpen Access PDFOpenAlex
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