The Impact of Depressive Symptoms on Emotional Sensitivity in Early‐Stage Alzheimer's Disease: Implications for Social and Emotional Well‐Being

Depression significantly impacts both emotion reading and real-life empathy in AD, including empathic concern and perspective-taking. Negative mood (dysphoria and hopelessness) hindered emotional connection despite having no effect on emotion reading. Increased mental rumination (worry and concerns about cognition) was linked to reduced empathic engagement, despite heightened emotion comprehension skills. These complex relationships underscore the importance of identifying the specific nature of depressive symptoms when evaluating individuals with early-stage AD, to better implement targeted interventions that preserve social engagement and emotional well-being.

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Publication Details

Journal
Alzheimer s & Dementia
Published
2025-12-01
DOI
https://doi.org/10.1002/alz70857_106130
Primary Topic
Dementia and Cognitive Impairment Research
Type
article
Field-Weighted Citation Impact
0.00
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article

The Impact of Depressive Symptoms on Emotional Sensitivity in Early‐Stage Alzheimer's Disease: Implications for Social and Emotional Well‐Being

Katherine Rankin, Bailey L Ortiz, Liberty Hebron, Angelina Quagletti et al.
Alzheimer s & Dementia
Dementia and Cognitive Impairment Research
article

The Impact of Depressive Symptoms on Emotional Sensitivity in Early‐Stage Alzheimer's Disease: Implications for Social and Emotional Well‐Being

Katherine Rankin, Bailey L Ortiz, Liberty Hebron, Angelina Quagletti, Joel H Kramer, Gil D. Rabinovici, Bruce L. Miller
article en

Abstract

Depression significantly impacts both emotion reading and real-life empathy in AD, including empathic concern and perspective-taking. Negative mood (dysphoria and hopelessness) hindered emotional connection despite having no effect on emotion reading. Increased mental rumination (worry and concerns about cognition) was linked to reduced empathic engagement, despite heightened emotion comprehension skills. These complex relationships underscore the importance of identifying the specific nature of depressive symptoms when evaluating individuals with early-stage AD, to better implement targeted interventions that preserve social engagement and emotional well-being.

Alzheimer s & DementiaVol. 21(S3)
Lawrence Berkeley National Laboratory (US), Palo Alto University (US), University of California, San Francisco (US), University of California System (US), University Memory and Aging Center (US), Alzheimer’s Disease Neuroimaging Initiative (US), Global Brain Health Institute (US)
Quality Education
Openalex Percentile: Top 33%
Dementia and Cognitive Impairment Research
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