Multiplexed pathological markers of white matter hyperintensities show greater vascular and inflammatory injury than neuronal damage

Vascular and glial pathology is most common in WMHs. Given that the astrocytic marker was only significant in the paired analysis, it may represent a more localized pathology. We are unsure why no neuronal pathology markers were identified in the WMH. This could mean, that neuronal injury is not as severe in WMH or there is widespread aging-related diffuse white matter injury that overshadows the WMH pathology.