Indications, Timing, and Outcome of Decompressive Craniectomy in Malignant Middle Cerebral Artery Infarction: A Swedish Multicenter Study

Indication and timing of DC as a treatment of MMI demonstrated notable discrepancies in surgical practice across centers and compared to landmark RCTs. However, despite differences in timing and indications for DC, the outcome did not differ significantly across centers. Our findings provide insight into the outcome of DC performed for MMI outside the strict criteria supported by level 1 evidence.

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Journal
World Neurosurgery
Published
2025-12-26
DOI
https://doi.org/10.1016/j.wneu.2025.124761
Primary Topic
Acute Ischemic Stroke Management
Type
article
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article

Indications, Timing, and Outcome of Decompressive Craniectomy in Malignant Middle Cerebral Artery Infarction: A Swedish Multicenter Study

Klas Holmgren, Alba Corell, Richard Ågren, Peter Lindvall et al.
World Neurosurgery
Acute Ischemic Stroke Management
article

Indications, Timing, and Outcome of Decompressive Craniectomy in Malignant Middle Cerebral Artery Infarction: A Swedish Multicenter Study

Klas Holmgren, Alba Corell, Richard Ågren, Peter Lindvall, Per Enblad, Emilia Muncan, Modar Alhamdan, Bjartur Sæmundsson, Robert Nilsson, Teodor Svedung Wettervik, Alexander Fletcher-Sandersjöö, Lars-Owe Koskinen
article en

Abstract

Indication and timing of DC as a treatment of MMI demonstrated notable discrepancies in surgical practice across centers and compared to landmark RCTs. However, despite differences in timing and indications for DC, the outcome did not differ significantly across centers. Our findings provide insight into the outcome of DC performed for MMI outside the strict criteria supported by level 1 evidence.

World NeurosurgeryVol. 206
Uppsala University (SE), Karolinska University Hospital (SE), Sahlgrenska University Hospital (SE), University of Gothenburg (SE), Umeå University (SE)
Good health and well-being
Openalex Percentile: Top 30%
Acute Ischemic Stroke Management
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Indications, Timing, and Outcome of Decompressive Craniectomy in Malignant Middle Cerebral Artery Infarction: A Swedish Multicenter Study — Klas Holmgren, Alba Corell, et al. · World Neurosurgery (2025) | TGRS Research Map | TGRS