Circulating microRNAs as Promising Biomarkers for Alzheimer's Disease: Insights from Human Plasma and Mouse Models

The 3xTg-AD mouse model exhibits plasma miRNA profile changes consistent with human miRNA molecular signature of AD, highlighting the potential of miRNAs as biomarkers for AD. This mice model also offers a valuable platform for studying the molecular mechanisms involving miRNAs in AD pathogenesis. Supported by the Polish National Science Centre grant OPUS 2022/47/B/NZ7/03005 and the EU Horizon 2020 Research and Innovation grant no 737390 (ArrestAD).

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Publication Details

Journal
Alzheimer s & Dementia
Published
2025-12-01
DOI
https://doi.org/10.1002/alz70856_103363
Primary Topic
MicroRNA in disease regulation
Type
article
Field-Weighted Citation Impact
0.00
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article

Circulating microRNAs as Promising Biomarkers for Alzheimer's Disease: Insights from Human Plasma and Mouse Models

Karolina Staniak, Aida Muntsant Soria, Urszula Wojda, Simran Yadav et al.
Alzheimer s & Dementia
MicroRNA in disease regulation
article

Circulating microRNAs as Promising Biomarkers for Alzheimer's Disease: Insights from Human Plasma and Mouse Models

Karolina Staniak, Aida Muntsant Soria, Urszula Wojda, Simran Yadav, Lydia Giménez Llort
article en

Abstract

The 3xTg-AD mouse model exhibits plasma miRNA profile changes consistent with human miRNA molecular signature of AD, highlighting the potential of miRNAs as biomarkers for AD. This mice model also offers a valuable platform for studying the molecular mechanisms involving miRNAs in AD pathogenesis. Supported by the Polish National Science Centre grant OPUS 2022/47/B/NZ7/03005 and the EU Horizon 2020 Research and Innovation grant no 737390 (ArrestAD).

Alzheimer s & DementiaVol. 21(S2)
Universitat Autònoma de Barcelona (ES), Instytut Biologii Doświadczalnej im. Marcelego Nenckiego (PL), Polish Academy of Sciences (PL)
Openalex Percentile: Top 33%
MicroRNA in disease regulation
DOIOpen Access PDFOpenAlex
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