Evaluation of GFAP and phosphorylated tau correlation in human blood using magnetic bead‐based electrochemical sensor

We evaluated the correlation between GFAP and p-tau levels in human blood using a magnetic bead-based electrochemical sensor for AD diagnosis. We could determine the extent of astrocyte activation in individuals with NC, MCI, and AD using a GFAP protein. Moreover, the cross-validation of the impedance change rates indicates that the AUC value for the multi-biomarkers is superior to that of a single biomarker. Successful validation of a point-of-care platform for blood biomarkers such as GFAP and p-tau could increase the diagnostic reliability of AD, which could forecast the prognosis of AD.