Monoamine Loss and Functional Connectivity Alterations in Patients With Parkinson's Disease and Depression
In depressed Parkinson's disease patients, monoaminergic deficits are present alongside abnormally increased connectivity within the striatum-mesolimbic circuitry, highlighting this pathway as a potential target for treatment.
Authors
- Olivier Barret (ORCID: https://orcid.org/0000-0003-4247-184X)
- Baolei Xu (ORCID: https://orcid.org/0000-0002-2211-5680)
- Xia Liu (ORCID: https://orcid.org/0000-0002-9209-0562)
- Shuying Liu
- Chun Zhang
- Hongwen Qiao
- Jie Lu
- Piu Chan
- Gilles D. Tamagnan
Institutions
- Centre National de la Recherche Scientifique (FR)
- Capital Medical University (CN)
- Commissariat à l'Énergie Atomique et aux Énergies Alternatives (FR)
- Université Paris-Saclay (FR)
- National Clinical Research Center for Digestive Diseases (CN)
- Chinese Institute for Brain Research (CN)
- CEA Paris-Saclay (FR)
- Elucid Bioimaging (US)
Publication Details
- Journal
- CNS Neuroscience & Therapeutics
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/cns.70705
- Primary Topic
- Neurological disorders and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Beijing Nova Program