Enhanced Sensitivity to Elevated Plasma <i>p</i> ‐Tau 217 with Proper Name Delayed Recall in the Preclinical Alzheimer's Cognitive Composite
Remarkably, substituting proper name delayed recall for logical memory total score improves sensitivity for tracking longitudinal cognitive decline related to AD blood-biomarker p-Tau217 group. Our study highlights a novel language measure that yielded composites more sensitive to AD-related preclinical changes. Follow-up analyses will investigate implications for screening and clinical trials.
Authors
- Randall S. Johnson (ORCID: https://orcid.org/0000-0002-4084-6639)
- Deling He (ORCID: https://orcid.org/0000-0003-4690-6871)
- Erin M. Jonaitis (ORCID: https://orcid.org/0009-0004-5091-8255)
- Rachael E. Wilson (ORCID: https://orcid.org/0000-0003-4197-7777)
- Kimberly D. Mueller (ORCID: https://orcid.org/0000-0001-8691-9517)
- Bruce P Hermann
- Rebecca E. Langhough
Institutions
- University of Wisconsin–Madison (US)
- University of Wisconsin Health (US)
- Wisconsin Division of Public Health (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_103547
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00