Intradermal Acupuncture for Moderate to Severe Dry Eye Disease: a pilot randomized controlled trial

Intradermal acupuncture showed comparable effectiveness to body acupuncture in relieving symptoms of moderate to severe DED, suggesting its potential as an alternative therapeutic option. While between-group differences were not definitive in this pilot study, the findings provide preliminary estimates to inform a future, properly powered non-inferiority trial aimed at determining whether IA can achieve clinically comparable outcomes with potential advantages in convenience and adherence.