Factors Associated with Atypical Cognitive Trajectories in Older Adults with Down Syndrome
In our sample of adults with DS and MCI-DS, 31.6% did not progress to dementia despite having high levels of amyloid PET. Those whose decline plateaued had more medical conditions and life stressors. Those with temporary decline had more psychiatric problems. Primary care physicians need to understand which reversible or treatable factors are most likely to lead to a misdiagnosis of prodromal AD and address them accordingly.
Authors
- Benjamin L. Handen (ORCID: https://orcid.org/0000-0001-9550-1665)
- Sharon J. Krinsky‐McHale (ORCID: https://orcid.org/0000-0002-7205-7319)
- Wayne Silverman (ORCID: https://orcid.org/0000-0002-7842-8600)
- Christy Hom (ORCID: https://orcid.org/0000-0003-0266-0961)
- Patrick J. Lao (ORCID: https://orcid.org/0000-0003-2243-3547)
- Sigan L. Hartley (ORCID: https://orcid.org/0000-0002-0186-6282)
- Florence Lai (ORCID: https://orcid.org/0000-0003-4354-0624)
- Jordan P. Harp (ORCID: https://orcid.org/0000-0003-2089-0883)
- Beau M. Ances (ORCID: https://orcid.org/0000-0003-3862-7397)
- Shahid Zaman
- Ira T. Lott (ORCID: https://orcid.org/0000-0002-3107-0752)
- Bradley T Christian
- Adam Brickman
- Diana K. Valencia
- Frederick A. Schmitt
- Mark Mapstone
- H. Diana Rosas
Institutions
- University of Wisconsin–Madison (US)
- Harvard University (US)
- University of Kentucky (US)
- University of Pittsburgh (US)
- University of California, Irvine (US)
- Washington University in St. Louis (US)
- University of Cambridge (GB)
- New York State Office for People With Developmental Disabilities (US)
- Massachusetts General Hospital (US)
- Institute on Aging (US)
- Columbia University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70857_105703
- Primary Topic
- Down syndrome and intellectual disability research
- Type
- article
- Field-Weighted Citation Impact
- 0.00