Does depression in Alzheimer's disease show evidence of differential gene expression in neurons or microglia compared to Alzheimer's disease without depression?
Although no individual gene reached significance, by using GSEA we have identified pathways which may contribute to the development of depression in AD, particularly in microglia.
Authors
- Mizuki Morisaki (ORCID: https://orcid.org/0000-0002-6741-9370)
- Jordan T. Lin (ORCID: https://orcid.org/0000-0002-4595-126X)
- Clive Ballard (ORCID: https://orcid.org/0000-0003-0022-5632)
- Peter Henley (ORCID: https://orcid.org/0000-0003-4905-482X)
- Lindsey I. Sinclair (ORCID: https://orcid.org/0000-0002-4776-4118)
- Emma Louise Dempster (ORCID: https://orcid.org/0000-0003-1257-5314)
- Professor Seth Love
Institutions
- University of Exeter (GB)
- University of Bristol (GB)
- Cardiff University (GB)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70857_105622
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00