Dietary Nitrate Intake and <scp>16S rRNA</scp> ‐Inferred Nitrite‐Generating Capacity of the Subgingival Microbiome May Influence Glucose Metabolism: Results From the Oral Infections Glucose Intolerance and Insulin Resistance Study ( <scp>ORIGINS</scp
A biomarker of higher microbial NO-generating capacity in subgingival plaque is associated with lower insulin and insulin resistance among individuals with lower dietary nitrate intake. Future trials evaluating the cardiometabolic benefits of nitrate-rich diets should incorporate measures of the entire oral microbiome.
Authors
- Panos N. Papapanou (ORCID: https://orcid.org/0000-0002-6538-3618)
- Jeanine M. Genkinger (ORCID: https://orcid.org/0000-0002-8438-0412)
- Ryan T. Demmer (ORCID: https://orcid.org/0000-0003-3429-0379)
- Sumith Roy (ORCID: https://orcid.org/0000-0002-8887-9835)
- Bruno Bohn (ORCID: https://orcid.org/0000-0001-8961-6968)
- Rebecca Molinsky (ORCID: https://orcid.org/0000-0001-9564-0147)
- Stephen Johnson (ORCID: https://orcid.org/0000-0003-0685-9863)
- P.C. Colombo (ORCID: https://orcid.org/0000-0003-4977-3285)
- David R. Jacobs
- B. J. Paster
- Charlene En Hui Goh
- Ching‐Yuan Chen
- Michael Rosenbaum
- Moïse Desvarieux
- Melana Yuzefpolskaya
- Rob Knight
Institutions
- University of Minnesota (US)
- Mayo Clinic (US)
- NewYork–Presbyterian Hospital (US)
- Harvard University (US)
- Inserm (FR)
- National University of Singapore (SG)
- Columbia University Irving Medical Center (US)
- University of California System (US)
- University of California San Diego (US)
- Sorbonne Paris Cité (FR)
- La Jolla Bioengineering Institute (US)
- Mayo Clinic in Florida (US)
- Centre de Recherche Épidémiologie et Statistique (FR)
- Columbia University (US)
Publication Details
- Journal
- Journal Of Clinical Periodontology
- Published
- 2025-12-25
- DOI
- https://doi.org/10.1111/jcpe.70084
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.00