Biomarker and cognitive associates of resistance to neocortical tau pathology in a pooled cohort
These findings suggest that baseline levels of MTL tau and age play a role in resisting the advancement of tauopathy into neocortical brain regions, and might be mediated by Aβ in early disease stages. The counter-intuitive association with cognition and brain reserve measures implies that tau resistance is most likely represented by those with greater cognitive impairment and lower reserve, as neocortical tau burden is much lower in clinically-normal older adults.
Authors
- Heidi I.L. Jacobs (ORCID: https://orcid.org/0000-0001-7620-3822)
- Oliver Langford (ORCID: https://orcid.org/0009-0006-8951-1326)
- Aaron P. Schultz (ORCID: https://orcid.org/0000-0002-0418-0999)
- Timothy J. Hohman (ORCID: https://orcid.org/0000-0002-3377-7014)
- Michael Donohue (ORCID: https://orcid.org/0000-0001-6026-2238)
- Rachel F. Buckley (ORCID: https://orcid.org/0000-0002-5356-5537)
- Bernard Hanseeuw (ORCID: https://orcid.org/0000-0002-3102-6778)
- Gillian Coughlan (ORCID: https://orcid.org/0000-0003-1806-702X)
- Colin Birkenbihl (ORCID: https://orcid.org/0000-0002-7212-7700)
- Julie C. Price
- Jane A. Brown (ORCID: https://orcid.org/0000-0002-2545-3693)
- Rebecca England Amariglio (ORCID: https://orcid.org/0009-0009-5878-8930)
- Jasmeer P. Chhatwal (ORCID: https://orcid.org/0000-0002-7792-1698)
- Hannah M Klinger
- Annie Li (ORCID: https://orcid.org/0009-0005-7020-5794)
- Madison Cuppels
- Maria Carrigan
- Reisa A. Sperling
- Keith A. Johnson
- Mabel Seto
- Michelle E. Farrell
- Michael J. Properzi
- Dorene M. Rentz
Institutions
- University of Southern California (US)
- Brigham and Women's Hospital (US)
- Harvard University (US)
- Massachusetts General Hospital (US)
- Athinoula A. Martinos Center for Biomedical Imaging (US)
- Amsterdam University of Applied Sciences (NL)
- Vanderbilt University Medical Center (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70857_106460
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00