Sex‐Modified Effects of <i>APOE</i> ‐ε4 on Spatial Patterns of Brain Atrophy: A Multi‐cohort Study
Our multi-cohort study demonstrates that APOE-ε4 carrier status influences both brain atrophy patterns and their progression. While baseline APOE-ε4 effects were female-specific, progression rates were sex-independent. These findings advance our understanding of sex-specific genetic influences on AD-related brain changes.
Authors
- Randall S. Johnson (ORCID: https://orcid.org/0000-0002-4084-6639)
- Michael Cuccaro
- Timothy J. Hohman (ORCID: https://orcid.org/0000-0002-3377-7014)
- Sarah Biber
- Derek B. Archer (ORCID: https://orcid.org/0000-0001-8638-0785)
- Logan C. Dumitrescu (ORCID: https://orcid.org/0000-0002-9782-9944)
- Christos A. Davatzikos (ORCID: https://orcid.org/0000-0002-1025-8561)
- Konstantinos Arfanakis (ORCID: https://orcid.org/0000-0001-9705-597X)
- Duygu Tosun (ORCID: https://orcid.org/0000-0001-5174-3910)
- Lisa Laverne Barnes
- Andrew Joel Saykin
- M C Zhang
- Walter W. Kukull
- Di Wang
- Guray Erus
- Mohamad Habes
- Yuhan Cui
- Barbara B. Bendlin
- Bennett A. Landman
- Arthur W. Toga
- David A. A. Bennett
- Julie A Schneider
- Shannon L Risacher
- The Alzheimer's Disease Sequencing Project (ADSP) Alzheimer's Disease Neuroimaging Initiative (ADNI)
- Paul M. Thompson
Institutions
- University of Southern California (US)
- Rush University Medical Center (US)
- University of Wisconsin–Madison (US)
- University of Miami (US)
- The University of Texas at San Antonio Health Science Center (US)
- University of California, San Francisco (US)
- Illinois Institute of Technology (US)
- Vanderbilt University (US)
- University of Washington (US)
- Institute for Neurodegenerative Disorders (US)
- Dr. John T. Macdonald Foundation (US)
- Wisconsin Division of Public Health (US)
- Artificial Intelligence in Medicine (Canada) (CA)
- Indiana University School of Medicine
- Rush University (US)
- Indiana University – Purdue University Indianapolis (US)
- University of Pennsylvania (US)
- Vanderbilt University Medical Center (US)
- The University of Texas Health Science Center at Houston (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_103183
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00