Sex‐Modified Effects of <i>APOE</i> ‐ε4 on Spatial Patterns of Brain Atrophy: A Multi‐cohort Study

Our multi-cohort study demonstrates that APOE-ε4 carrier status influences both brain atrophy patterns and their progression. While baseline APOE-ε4 effects were female-specific, progression rates were sex-independent. These findings advance our understanding of sex-specific genetic influences on AD-related brain changes.

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Publication Details

Journal
Alzheimer s & Dementia
Published
2025-12-01
DOI
https://doi.org/10.1002/alz70856_103183
Primary Topic
Dementia and Cognitive Impairment Research
Type
article
Field-Weighted Citation Impact
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article

Sex‐Modified Effects of APOE ‐ε4 on Spatial Patterns of Brain Atrophy: A Multi‐cohort Study

Randall S. Johnson, Michael Cuccaro, Timothy J. Hohman, Sarah Biber et al.
Alzheimer s & Dementia
Dementia and Cognitive Impairment Research
article

Sex‐Modified Effects of APOE ‐ε4 on Spatial Patterns of Brain Atrophy: A Multi‐cohort Study

Randall S. Johnson, Michael Cuccaro, Timothy J. Hohman, Sarah Biber, Derek B. Archer, Logan C. Dumitrescu, Christos A. Davatzikos, Konstantinos Arfanakis, Duygu Tosun, Lisa Laverne Barnes, Andrew Joel Saykin, M C Zhang, Walter W. Kukull, Di Wang, Guray Erus, Mohamad Habes, Yuhan Cui, Barbara B. Bendlin, Bennett A. Landman, Arthur W. Toga, David A. A. Bennett, Julie A Schneider, Shannon L Risacher, The Alzheimer's Disease Sequencing Project (ADSP) Alzheimer's Disease Neuroimaging Initiative (ADNI), Paul M. Thompson
article en

Abstract

Our multi-cohort study demonstrates that APOE-ε4 carrier status influences both brain atrophy patterns and their progression. While baseline APOE-ε4 effects were female-specific, progression rates were sex-independent. These findings advance our understanding of sex-specific genetic influences on AD-related brain changes.

Alzheimer s & DementiaVol. 21(S2)
University of Southern California (US), Rush University Medical Center (US), University of Wisconsin–Madison (US), University of Miami (US), The University of Texas at San Antonio Health Science Center (US), University of California, San Francisco (US), Illinois Institute of Technology (US), Vanderbilt University (US), University of Washington (US), Institute for Neurodegenerative Disorders (US), Dr. John T. Macdonald Foundation (US), Wisconsin Division of Public Health (US), Artificial Intelligence in Medicine (Canada) (CA), Indiana University School of Medicine, Rush University (US), Indiana University – Purdue University Indianapolis (US), University of Pennsylvania (US), Vanderbilt University Medical Center (US), The University of Texas Health Science Center at Houston (US)
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Openalex Percentile: Top 33%
Dementia and Cognitive Impairment Research
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