V-Cornea: A computational model of corneal epithelium homeostasis, injury, and recovery
V-Cornea's modular CompuCell3D implementation is easily extensible to incorporate additional recovery and injury mechanisms. Future versions will include more realistic basement membrane dynamics and explicit representation of stromal tissue and immune response, to improve predictivity for moderate injuries. This virtual-tissue approach shows potential not only for toxicological assessments but also for drug discovery and therapy optimization by providing a platform to test interventions and predict outcomes across various injury scenarios.
Authors
- Michael Getz (ORCID: https://orcid.org/0000-0001-9886-8454)
- James A. Glazier (ORCID: https://orcid.org/0000-0003-3634-190X)
- Catherine Mahony (ORCID: https://orcid.org/0000-0003-0563-8567)
- Joel Vanin (ORCID: https://orcid.org/0000-0001-9227-9667)
- Thomas B. Knudsen
Institutions
- Procter & Gamble (United Kingdom) (GB)
- Indiana University Bloomington (US)
- Biocom (US)
Publication Details
- Journal
- PLoS Computational Biology
- Published
- 2025-12-26
- DOI
- https://doi.org/10.1371/journal.pcbi.1013410
- Primary Topic
- Corneal Surgery and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00