V-Cornea: A computational model of corneal epithelium homeostasis, injury, and recovery

V-Cornea's modular CompuCell3D implementation is easily extensible to incorporate additional recovery and injury mechanisms. Future versions will include more realistic basement membrane dynamics and explicit representation of stromal tissue and immune response, to improve predictivity for moderate injuries. This virtual-tissue approach shows potential not only for toxicological assessments but also for drug discovery and therapy optimization by providing a platform to test interventions and predict outcomes across various injury scenarios.

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Publication Details

Journal
PLoS Computational Biology
Published
2025-12-26
DOI
https://doi.org/10.1371/journal.pcbi.1013410
Primary Topic
Corneal Surgery and Treatments
Type
article
Field-Weighted Citation Impact
0.00
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article

V-Cornea: A computational model of corneal epithelium homeostasis, injury, and recovery

Michael Getz, James A. Glazier, Catherine Mahony, Joel Vanin et al.
PLoS Computational Biology
Corneal Surgery and Treatments
article

V-Cornea: A computational model of corneal epithelium homeostasis, injury, and recovery

Michael Getz, James A. Glazier, Catherine Mahony, Joel Vanin, Thomas B. Knudsen
article en

Abstract

V-Cornea's modular CompuCell3D implementation is easily extensible to incorporate additional recovery and injury mechanisms. Future versions will include more realistic basement membrane dynamics and explicit representation of stromal tissue and immune response, to improve predictivity for moderate injuries. This virtual-tissue approach shows potential not only for toxicological assessments but also for drug discovery and therapy optimization by providing a platform to test interventions and predict outcomes across various injury scenarios.

PLoS Computational BiologyVol. 21(12)
Procter & Gamble (United Kingdom) (GB), Indiana University Bloomington (US), Biocom (US)
Openalex Percentile: Top 31%
Corneal Surgery and Treatments
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V-Cornea: A computational model of corneal epithelium homeostasis, injury, and recovery — Michael Getz, James A. Glazier, et al. · PLoS Computational Biology (2025) | TGRS Research Map | TGRS