Microglia as a key player in Aβ‐related astrocyte reactivity

Our results suggest that microglial activation is a major phenomenon linking Aβ and astrocyte reactivity in the living AD brain. These findings help to elucidate the intricate crosstalk between microglia and astrocytes in the AD brain, offering insights for the development of glia-targeting therapies.

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Publication Details

Journal
Alzheimer s & Dementia
Published
2025-12-01
DOI
https://doi.org/10.1002/alz70856_102677
Primary Topic
Neuroinflammation and Neurodegeneration Mechanisms
Type
article
Field-Weighted Citation Impact
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article

Microglia as a key player in Aβ‐related astrocyte reactivity

Dana Tudorascu, Tharick Ali Pascoal, Douglas Teixeira Leffa, Nesrine Rahmouni et al.
Alzheimer s & Dementia
Neuroinflammation and Neurodegeneration Mechanisms
article

Microglia as a key player in Aβ‐related astrocyte reactivity

Dana Tudorascu, Tharick Ali Pascoal, Douglas Teixeira Leffa, Nesrine Rahmouni, Wagner S. Brum, Giovanna Carello‐Collar, Lucas Porcello Schilling, Mychael V. Lourenco, Marco Antônio De Bastiani, Arthur C. Macedo, Bruna Bellaver, Gallen Triana‐Baltzer, Firoza Zubeida Lussier, Cristiano Schaffer Aguzzoli, Hartmuth C. Kolb, Kaj Blennow, Jenna Stevenson, Pamela C.L. Ferreira, Guilherme Povala, João Pedro Ferrari‐Souza, Henrik Zetterberg, Eduardo R. Zimmer, Joseph Therriault, Nicholas J. Ashton, Serge Gauthier, Ilaria Pola, Stijn Servaes, Diogo O. Souza, Andrea L. Benedet, Wyllians Vendramini Borelli, Pedro Rosa‐Neto
article en

Abstract

Our results suggest that microglial activation is a major phenomenon linking Aβ and astrocyte reactivity in the living AD brain. These findings help to elucidate the intricate crosstalk between microglia and astrocytes in the AD brain, offering insights for the development of glia-targeting therapies.

Alzheimer s & DementiaVol. 21(S2)
Universidade Federal do Rio de Janeiro (BR), Universidade Federal do Rio Grande do Sul (BR), Johnson & Johnson (United States) (US), University of Arizona (US), University of Pittsburgh (US), Instituto do Cérebro (BR), Enigma Diagnostics (United Kingdom) (GB), McGill University (CA), University of Gothenburg (SE)
Openalex Percentile: Top 38%
Neuroinflammation and Neurodegeneration Mechanisms
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