Neuropsychiatric Symptom Phenotype Prevalence in Diverse Older Adults with Alzheimer's Disease
Prevalence of the AS phenotype was higher than the PA phenotype in the overall sample. Among PA+ individuals, symptoms were more likely to occur early in the disease. Prevalence of AS and PA phenotypes differed by race, suggesting the need for further research in individuals of diverse ancestries to examine ancestry-specific genetic determinants, molecular pathways, and drug targets to develop tailored treatments.
Authors
- Michael Cuccaro
- Timothy J. Hohman (ORCID: https://orcid.org/0000-0002-3377-7014)
- Nicholas R. Ray
- Gary W. Beecham (ORCID: https://orcid.org/0000-0002-7061-6332)
- Colin Stein (ORCID: https://orcid.org/0009-0005-1990-4426)
- Christiane Reitz (ORCID: https://orcid.org/0000-0001-8757-7889)
- Masood Manoochehri (ORCID: https://orcid.org/0000-0001-5818-180X)
- Jiji T. Kurup (ORCID: https://orcid.org/0000-0001-6291-3911)
- Edward D. Huey (ORCID: https://orcid.org/0000-0002-8295-5884)
- Alyssa N. De Vito (ORCID: https://orcid.org/0000-0002-4078-3869)
- Ajneesh Kumar (ORCID: https://orcid.org/0000-0001-5513-4135)
- Pamela del Rosario
- ADSP NPS Harmonization Working Group
Institutions
- University of Miami (US)
- Vanderbilt University (US)
- Brown University (US)
- Columbia University Irving Medical Center (US)
- Dr. John T. Macdonald Foundation (US)
- Wake Forest University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70857_107007
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00