Temporal ordering of blood metabolites and CSF biomarkers reveals early changes in lipid composition in Alzheimer's disease
Our results suggest that specific HDL lipid composition changes may occur very early in the AD cascade, slightly before or concurrent with CSF Aβ42 alterations. These findings support the potential utility of blood metabolite measures, particularly the phospholipids to total lipids ratio in medium HDL, as early AD biomarkers. Further research and replication in independent cohorts are needed to confirm these observations and advance non-invasive AD screening.
Authors
- Matthias Arnold (ORCID: https://orcid.org/0000-0002-9736-7233)
- Tianchuan Gao
- Rima F Kaddurah-Daouk (ORCID: https://orcid.org/0000-0003-1858-5732)
- Pradeep Varathan
- Meichen Yu (ORCID: https://orcid.org/0009-0009-2228-1417)
- Andrew Joel Saykin
- Kwangsik Nho
- Yen‐Ning Huang
- Jingwen Yan
Institutions
- University of Indianapolis (US)
- Duke University (US)
- Indianapolis Zoo (US)
- Helmholtz Zentrum München (DE)
- Indiana University Bloomington (US)
- Gesellschaft für Hochschulforschung (DE)
- Duke Medical Center (US)
- German Center for Diabetes Research (DE)
- Indiana University School of Medicine
- Indiana University – Purdue University Indianapolis (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_104093
- Primary Topic
- Metabolomics and Mass Spectrometry Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00