Efficacy of a synuclein and tau fibril targeting drug in vivo

While higher or longer dosing might disaggregate and clear insoluble fibrils, this initial study suggests oral dosing produces pleiotropic CNS activity against both aSyn and tau pre-fibrillar oligomers implicated in the neurotoxicity, seeding and spreading of two major proteinopathies.

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Publication Details

Journal
Alzheimer s & Dementia
Published
2025-12-01
DOI
https://doi.org/10.1002/alz70859_106249
Primary Topic
Parkinson's Disease Mechanisms and Treatments
Type
article
Field-Weighted Citation Impact
0.00
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article

Efficacy of a synuclein and tau fibril targeting drug in vivo

Ke Hou, Mychica Jones, David Eisenberg, Sally A. Frautschy et al.
Alzheimer s & Dementia
Parkinson's Disease Mechanisms and Treatments
article

Efficacy of a synuclein and tau fibril targeting drug in vivo

Ke Hou, Mychica Jones, David Eisenberg, Sally A. Frautschy, Cansheng Zhu, Gregory M. Cole, Kapil Manglani, Alex Bombino
article en

Abstract

While higher or longer dosing might disaggregate and clear insoluble fibrils, this initial study suggests oral dosing produces pleiotropic CNS activity against both aSyn and tau pre-fibrillar oligomers implicated in the neurotoxicity, seeding and spreading of two major proteinopathies.

Alzheimer s & DementiaVol. 21(S5)
West Los Angeles College (US), United States Department of Veterans Affairs (US), Howard Hughes Medical Institute (US), University of California, Los Angeles (US), UCLA Health (US), Foundation for Psychocultural Research (US), Geriatric Research Education and Clinical Center (US), VA Greater Los Angeles Healthcare System (US)
Good health and well-being
Openalex Percentile: Top 31%
Parkinson's Disease Mechanisms and Treatments
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Efficacy of a synuclein and tau fibril targeting drug in vivo — Ke Hou, Mychica Jones, et al. · Alzheimer s & Dementia (2025) | TGRS Research Map | TGRS