Enhancing structural insights for advanced drug discovery by mitigating protein crystal damage
To advance drug discovery, the structural biology community must adopt unified standards for data validation and experimental documentation. High-quality, reproducible structures are essential for minimizing artifacts and supporting AI-driven modeling and screening. A coordinated effort to integrate damage-aware practices and metadata standards will enhance the fidelity of structural data and its utility in therapeutic innovation.
Authors
- Michał Gucwa (ORCID: https://orcid.org/0000-0003-0591-9713)
- Krzysztof Murzyn (ORCID: https://orcid.org/0000-0002-7064-9900)
- Jerzy Bazak (ORCID: https://orcid.org/0000-0001-8283-4014)
- Michał Markiewicz (ORCID: https://orcid.org/0000-0002-7159-9343)
- Wojciech Dec (ORCID: https://orcid.org/0009-0000-9312-9804)
- Wladek Minor
Institutions
- Jagiellonian University (PL)
- University of Virginia (US)
Publication Details
- Journal
- Expert Opinion on Drug Discovery
- Published
- 2025-12-26
- DOI
- https://doi.org/10.1080/17460441.2025.2605354
- Primary Topic
- Enzyme Structure and Function
- Type
- article
- Field-Weighted Citation Impact
- 0.00