Role of gut microbiota‐derived metabolites in neurodegenerative disorders involving protein misfolding and C9orf72 expansion associated with dementia.
Outcomes from our studies link gut microbiota with mechanisms underlying PD and suggest the feasibility of developing GMP26 as a means to simultaneously target both α-syn misfolding and C9orf72 expansion to increase the likelihood of therapeutic efficacy in PD, ALS, FTD patients with C9orf72 expansion.
Authors
- Kenjiro Ono (ORCID: https://orcid.org/0000-0001-8454-6155)
- Giulio Maria Pasinetti (ORCID: https://orcid.org/0000-0002-1524-5196)
- Nicole Less
- Tom Lloyd
Institutions
- Kanazawa University (JP)
- Loyola University Maryland (US)
- Kanazawa Medical University (JP)
- James J. Peters VA Medical Center (US)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70859_107287
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.00