Correlating antemortem amyloid PET burden, postmortem MRI volumes, with neuropathological measures: Insights from Down syndrome and Alzheimer's disease cohorts
In DS, antemortem Aβ PET burden is associated with advanced LATE-NC stage but not with postmortem amygdala or hippocampal volumes. In ADRC cohort, Aβ burden correlates with postmortem amyloid plaque, neurofibrillary tangle, and neuritic plaque pathology.
Authors
- Julia Kofler (ORCID: https://orcid.org/0000-0003-4298-7328)
- Dana Tudorascu (ORCID: https://orcid.org/0000-0003-4675-3692)
- Benjamin L. Handen (ORCID: https://orcid.org/0000-0001-9550-1665)
- Charles M. Laymon (ORCID: https://orcid.org/0000-0002-5966-7219)
- William H. Yong
- Miloš D. Ikonomović (ORCID: https://orcid.org/0000-0002-8745-3293)
- Sigan L. Hartley (ORCID: https://orcid.org/0000-0002-0186-6282)
- Florence Lai (ORCID: https://orcid.org/0000-0003-4354-0624)
- Davneet Minhas (ORCID: https://orcid.org/0000-0002-0217-6777)
- Julie C. Price
- Shahid Zaman
- Tamer S. Ibrahim
- Bradley T Christian
- Tales Santini
- Weiquan Luo
- Adam Brickman
- Ann D Cohen
- Oscar L Lopez
- Elizabeth Head
- Mark Mapstone
- Jr‐Jiun Liou
- Victor L Villemagne
- H. Diana Rosas
Institutions
- University of Wisconsin–Madison (US)
- Harvard University (US)
- University of Pittsburgh (US)
- University of California, Irvine (US)
- University of Cambridge (GB)
- Massachusetts General Hospital (US)
- Columbia University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_103737
- Primary Topic
- Down syndrome and intellectual disability research
- Type
- article
- Field-Weighted Citation Impact
- 0.00