Precise Estimation Of Heterogenous Global Tau Burden In The Brain Sheds Light On Cognitive Resilience Mechanisms
The significant regions identified by THETA, showing reduced tau and preserved cortical thickness, combined with the clear offset in progression models between resilient and typical AD, suggest that THETA may help uncover pathological tau mechanisms that differentiate these groups. These findings highlight the potential of THETA to provide valuable insights into resilience mechanisms and enhance our understanding of AD.
Authors
- Val J. Lowe (ORCID: https://orcid.org/0000-0002-5612-1667)
- Jeffrey L. Gunter (ORCID: https://orcid.org/0000-0001-7813-9078)
- R. Petersen
- Jonathan Graff‐Radford
- Scott A. Przybelski (ORCID: https://orcid.org/0009-0009-3437-3773)
- Robel K Gebre (ORCID: https://orcid.org/0000-0002-5746-0994)
- Sheelakumari Raghavan
- David S. Knopman
- Clifford R. Jack
- Prashanthi Vemuri
Institutions
- Mayo Clinic in Arizona (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_103992
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00