Head‐to‐head trajectories of MK6240, Flortaucipir, and plasma <i>p</i> ‐tau217 as a function of Aβ
MK6240 becomes abnormal at lower levels of Aβ burden compared to plasma p-tau217 and Flortaucipir. The relatively high prevalence of discordant tau PET positive or plasma p-tau217 positive and suggests that some individuals may show tau PET positivity first, while others may exhibit plasma p-tau217 positivity first. The distinct cognitive profiles of this groups suggest potential clinical relevance, warranting further investigation.
Authors
- Val J. Lowe (ORCID: https://orcid.org/0000-0002-5612-1667)
- Dana Tudorascu (ORCID: https://orcid.org/0000-0003-4675-3692)
- Tharick Ali Pascoal (ORCID: https://orcid.org/0000-0001-9057-8014)
- Belén Pascual (ORCID: https://orcid.org/0000-0002-4467-7406)
- Joseph C. Masdeu (ORCID: https://orcid.org/0000-0001-9955-6954)
- Guilherme Bauer‐Negrini (ORCID: https://orcid.org/0000-0003-0956-557X)
- Bruna Bellaver (ORCID: https://orcid.org/0000-0002-2212-3373)
- Suzanne L. Baker (ORCID: https://orcid.org/0000-0003-0209-3127)
- Firoza Zubeida Lussier (ORCID: https://orcid.org/0000-0002-6877-4825)
- David Soleimani‐Meigooni
- Juan M. Fortea (ORCID: https://orcid.org/0000-0002-1340-638X)
- Hwamee Oh (ORCID: https://orcid.org/0000-0003-1156-5704)
- Pamela C.L. Ferreira
- Livia Amaral
- Guilherme Povala
- Carolina Soares
- Andreia Rocha
- Thomas K Karikari
- Brian A. Gordon
- Pedro Rosa‐Neto
Institutions
- Houston Methodist (US)
- Lawrence Berkeley National Laboratory (US)
- University of Pittsburgh (US)
- University of California, San Francisco (US)
- Washington University in St. Louis (US)
- Brown University (US)
- Hospital de Sant Pau (ES)
- University Memory and Aging Center (US)
- Mayo Clinic in Arizona (US)
- McGill University (CA)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70857_105968
- Primary Topic
- Medical Imaging Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00