Novel CSF glial‐related biomarkers reflect Alzheimer's and Parkinson's pathological changes
This study identified 485 glial-related CSF proteins altered in AD or PD. We also uncovered distinct glial protein clusters across AD pseudo-progression and their association with Aβ burden in the brain, highlighting potential glial biomarkers for neurodegenerative disease progression. These findings can help uncover the glial heterogeneity present in AD and PD.
Authors
- Luiza Santos Machado (ORCID: https://orcid.org/0000-0001-8387-3832)
- Dzeneta Vizlin‐Hodzic (ORCID: https://orcid.org/0000-0002-9696-7982)
- Kaj Blennow
- Guilherme Povala
- Henrik Zetterberg
- Eduardo R. Zimmer
- Ilaria Pola
- Andrea L. Benedet
- Nicholas J. Ashton
- Pedro Rosa‐Neto
Institutions
- Universidade Federal do Rio Grande do Sul (BR)
- University of Pittsburgh (US)
- Profu (Sweden) (SE)
- Banner Alzheimer’s Institute
- McGill University (CA)
- University of Gothenburg (SE)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_103748
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00