102P CD4+ CAR-T cells induceimmunogenic cell death through noncanonical extracellular vesicle

Recently, CD4+ chimeric antigen receptor (CAR) T cells have emerged to play a pivotal role in CAR-T therapy. Besides the well acknowledged helper functions, it has been recognized that CD4+ CAR-T cells also possess direct target killing capacity. However, the unique killing mechanism specific for CD4+ CAR-T cells and their contribution to the efficacy of CAR-T therapy has not been thoroughly understood.

Authors

Publication Details

Journal
Immuno-Oncology Technology
Published
2025-12-01
DOI
https://doi.org/10.1016/j.iotech.2025.101187
Primary Topic
CAR-T cell therapy research
Type
article
Field-Weighted Citation Impact
0.00
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article

102P CD4+ CAR-T cells induceimmunogenic cell death through noncanonical extracellular vesicle

H. Xian, H. Liu, Y. Wang
Immuno-Oncology Technology
CAR-T cell therapy research
article

102P CD4+ CAR-T cells induceimmunogenic cell death through noncanonical extracellular vesicle

H. Xian, H. Liu, Y. Wang
article en

Abstract

Recently, CD4+ chimeric antigen receptor (CAR) T cells have emerged to play a pivotal role in CAR-T therapy. Besides the well acknowledged helper functions, it has been recognized that CD4+ CAR-T cells also possess direct target killing capacity. However, the unique killing mechanism specific for CD4+ CAR-T cells and their contribution to the efficacy of CAR-T therapy has not been thoroughly understood.

Immuno-Oncology TechnologyVol. 28
Openalex Percentile: Top 31%
CAR-T cell therapy research
DOIOpen Access PDFOpenAlex
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