54P NLR/PLR + TILs as potential biomarkers in early TNBC patients receiving neo-adjuvant chemo-immunotherapy

Prognostic and predictive biomarkers in early triple-negative breast cancer (eTNBC) patients (pts) is challenging. As the role of TILs has been widely investigated (1), few data are available about the role of Neutrophil-to-Lymphocite Ratio (NLR) and Platelet-to-Lymphocytes Ratio (PLR). We investigated the predictive role of NLR and PLR in terms of pCR in 29 eTNBC pts treated with neoadjuvant Pembrolizumab-Carboplatin/Paclitaxel → Pembrolizumab-EC.

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Journal
Immuno-Oncology Technology
Published
2025-12-01
DOI
https://doi.org/10.1016/j.iotech.2025.101137
Primary Topic
Inflammatory Biomarkers in Disease Prognosis
Type
article
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article

54P NLR/PLR + TILs as potential biomarkers in early TNBC patients receiving neo-adjuvant chemo-immunotherapy

ME Cazzaniga, F.F. Pepe, K. Mohammadi, S. Capici et al.
Immuno-Oncology Technology
Inflammatory Biomarkers in Disease Prognosis
article

54P NLR/PLR + TILs as potential biomarkers in early TNBC patients receiving neo-adjuvant chemo-immunotherapy

ME Cazzaniga, F.F. Pepe, K. Mohammadi, S. Capici, G. Passarella, C. Dibella, K. Yazdanpanah Ardakani
article en

Abstract

Prognostic and predictive biomarkers in early triple-negative breast cancer (eTNBC) patients (pts) is challenging. As the role of TILs has been widely investigated (1), few data are available about the role of Neutrophil-to-Lymphocite Ratio (NLR) and Platelet-to-Lymphocytes Ratio (PLR). We investigated the predictive role of NLR and PLR in terms of pCR in 29 eTNBC pts treated with neoadjuvant Pembrolizumab-Carboplatin/Paclitaxel → Pembrolizumab-EC.

Immuno-Oncology TechnologyVol. 28
Azienda Ospedaliera San Gerardo (IT), University of Milano-Bicocca (IT)
Good health and well-being
Openalex Percentile: Top 31%
Inflammatory Biomarkers in Disease Prognosis
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