Effects of a PPAR delta agonist in a tauopathy mouse model

OLM testing evaluates dorsal hippocampus long term memory function and is transcription based. Y-maze is non-transcription based and studies short-term memory function and spatial recognition. Several relevant brain regions, including the entorhinal cortex and ventromedial prefrontal cortex, are required for ORM. Significantly higher discrimination index (DI) scores were observed with OLM testing at 11 months of age in the T3D-959 treatment group compared to saline, which demonstrates that T3D rescues hippocampal long term memory function better than saline. This is a potentially important finding that indicates that T3D-959 can impact the hippocampus to preserve long term memory function.