Amotivation associated with altered latent effort‐based decision‐making processes in Alzheimer's and Parkinson's disease

Loss of motivation in AD and PD is associated with disrupted effort-based decision-making processes, including speed of information accumulation, distance between decision options, information encoding and response execution, and bias to choose to do nothing. In addition, AD more generally is associated with greater decision noise, and reduced ability to integrate effort information on choices. In sum, decision-making tasks are a promising method to investigate the cognitive processes underlying motivational loss in neurodegeneration.

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Publication Details

Journal
Alzheimer s & Dementia
Published
2025-12-01
DOI
https://doi.org/10.1002/alz70857_105243
Primary Topic
Neural and Behavioral Psychology Studies
Type
article
Field-Weighted Citation Impact
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article

Amotivation associated with altered latent effort‐based decision‐making processes in Alzheimer's and Parkinson's disease

Bryan B Chen, Nora Vanegas, Edward D. Huey, Yunglin Gazes et al.
Alzheimer s & Dementia
Neural and Behavioral Psychology Studies
article

Amotivation associated with altered latent effort‐based decision‐making processes in Alzheimer's and Parkinson's disease

Bryan B Chen, Nora Vanegas, Edward D. Huey, Yunglin Gazes, Zhu Jin, Hideo Suzuki, Seonjoo Lee, Sarah R. Heibronner, Campbell J Le Heron, Lee‐Anne Morris, Ana Marin
article en

Abstract

Loss of motivation in AD and PD is associated with disrupted effort-based decision-making processes, including speed of information accumulation, distance between decision options, information encoding and response execution, and bias to choose to do nothing. In addition, AD more generally is associated with greater decision noise, and reduced ability to integrate effort information on choices. In sum, decision-making tasks are a promising method to investigate the cognitive processes underlying motivational loss in neurodegeneration.

Alzheimer s & DementiaVol. 21(S3)
Baylor College of Medicine (US), University of Canterbury (NZ), Brown University (US), Columbia University Irving Medical Center (US), Columbia University (US), University of Otago (NZ)
Peace, Justice and strong institutions
Openalex Percentile: Top 32%
Neural and Behavioral Psychology Studies
DOIOpen Access PDFOpenAlex
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Amotivation associated with altered latent effort‐based decision‐making processes in Alzheimer's and Parkinson's disease — Bryan B Chen, Nora Vanegas, et al. · Alzheimer s & Dementia (2025) | TGRS Research Map | TGRS