Effects of in vivo Lewy body pathology on neuropsychiatric symptoms across the Alzheimer's disease continuum
Our results suggest that in vivo-measured LB pathology is associated with a higher frequency of neuropsychiatric symptoms, with apathy, motor disturbances, appetite changes, anxiety, and psychosis as potential early neuropsychiatric manifestations of LB pathology in individuals across the AD continuum. These findings underscore the potential of in vivo LB detection as a marker for identifying individuals at elevated risk of neuropsychiatric symptoms, both in clinical trials and in clinical practice.
Authors
- Dana Tudorascu (ORCID: https://orcid.org/0000-0003-4675-3692)
- Tharick Ali Pascoal (ORCID: https://orcid.org/0000-0001-9057-8014)
- Douglas Teixeira Leffa (ORCID: https://orcid.org/0000-0002-4890-8451)
- Guilherme Bauer‐Negrini (ORCID: https://orcid.org/0000-0003-0956-557X)
- Matheus Scarpatto Rodrigues (ORCID: https://orcid.org/0000-0002-7794-6588)
- Arthur C. Macedo (ORCID: https://orcid.org/0000-0002-3957-0284)
- Bruna Bellaver (ORCID: https://orcid.org/0000-0002-2212-3373)
- Firoza Zubeida Lussier (ORCID: https://orcid.org/0000-0002-6877-4825)
- Marina Scop Medeiros
- Pamela C.L. Ferreira
- Livia Amaral
- Guilherme Povala
- Carolina Soares
- João Pedro Ferrari‐Souza
- Eduardo R. Zimmer
- Joseph Therriault
- Pedro Rosa‐Neto
Institutions
- Universidade Federal do Rio Grande do Sul (BR)
- University of Pittsburgh (US)
- McGill University (CA)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70857_106523
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00