Rightward White Matter Disease is Correlated to Intraplaque Hemorrhage

Previous studies suggest more injury in the right hemisphere for subjects with small vessel disease, and this work supports this finding. With rightward WML asymmetry being strongly associated with IPH, this could be reflecting a surrogate marker for overall vascular disease and its contribution to brain health and dementia. Automated WML biomarkers can be used to identify these high-risk patients and guide early interventions for subjects with vascular disease and dementia. Future work should validate these findings in larger, longitudinal datasets to enhance clinical applications.