Time-dependent effects of formalin fixation on magnetic resonance imaging relaxation times in ex vivo human thrombus tissue
Formalin fixation substantially alters T1 and T2 relaxation times in thrombus tissue, while T2* remains relatively stable. These findings highlight the necessity of accounting for fixation effects and patient-specific biological factors when designing and interpreting <i>ex vivo</i> thrombus MRI data and developing imaging biomarkers.
Authors
- Enikő Pomozi (ORCID: https://orcid.org/0000-0003-0488-2736)
- Judit Csőre (ORCID: https://orcid.org/0000-0003-3792-527X)
- C. Jordan (ORCID: https://orcid.org/0000-0002-6483-9177)
- Christof Karmonik (ORCID: https://orcid.org/0000-0002-6695-9535)
- Trisha Roy (ORCID: https://orcid.org/0000-0002-2180-1275)
- Alexander B. Crichton
Institutions
- Semmelweis University (HU)
- Houston Methodist (US)
- Methodist Hospital (US)
- Imaging Center (US)
- University of Birmingham (GB)
- Texas A&M University (US)
Publication Details
- Journal
- Annals of Translational Medicine
- Published
- 2025-12-01
- DOI
- https://doi.org/10.21037/atm-25-108
- Primary Topic
- Protease and Inhibitor Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00