An optimized cognitive biomarker that accurately predicts future cognitive decline and improves the detection of MCI and early dementia

A 4-5 minute brief optimized cognitive test can dramatically outperform the 10-14 minute MoCA in detecting MCI, and it can predict future decline to dementia comparably to, or better than, a clinical diagnosis made by clinicians with access to extensive cognitive and clinical information. This test could improve MCI detection in the more than 52 million people in the US age 65 or over.