Associations between Quantitative Neuronal Loss Measures and Postmortem MRI Atrophy Measures in the Human Medial Temporal Lobe in AD and LATE
These initial feasibility results in two sections in 24 brain donors encourage us to apply this pipeline to a larger dataset of paired postmortem MRI and serial histology sections (Ravikumar et al., 2024) and to study associations between tau pathology, neuronal loss, and MRI-based measures of atrophy, with the aim of better differentiating atrophy linked to LATE and AD.
Authors
- Ricardo Gómez Insausti
- Amanda E Denning (ORCID: https://orcid.org/0009-0005-2531-9346)
- María del Pilar Marcos Rabal
- Ranjit Ittyerah
- Daniel T. Ohm (ORCID: https://orcid.org/0000-0002-7930-5434)
- Theresa Schuck
- Niyousha Sadeghpour (ORCID: https://orcid.org/0000-0001-8665-0335)
- Sydney Lim (ORCID: https://orcid.org/0000-0002-5359-4661)
- David A. Wolk (ORCID: https://orcid.org/0000-0002-3554-3481)
- Winifred Trotman (ORCID: https://orcid.org/0000-0002-4121-1889)
- Noemí Villaseca
- Jose Gonzalez (ORCID: https://orcid.org/0000-0003-4612-1943)
- John Robinson (ORCID: https://orcid.org/0000-0001-6858-2367)
- Esther Buendia
- María del Mar Arroyo Jiménez
- M. Avilla Muñoz
- María M. Martín
- Lisa M Levorse
- Alicia Vela
- Karthik Prabhakaran
- Petter Clemensson (ORCID: https://orcid.org/0000-0002-5238-9084)
- Laura E.M. Wisse
- Paul A. Yushkevich
- Sandra Cebada Sanchez
- Sadhana Ravikumar
- Eddie B Lee
- David J. Irwin
- Christopher D. Brown
- Ana M Insausti
- M. Dylan Tisdall
- Sandhitsu R. Das
- Carlos de la Rosa Prieto
Institutions
- King's College London (GB)
- Lund University (SE)
- Institute on Aging (US)
- Kitware (United States) (US)
- University of Castilla-La Mancha (ES)
- University of Pennsylvania (US)
- Universidad de Navarra (ES)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_103753
- Primary Topic
- Functional Brain Connectivity Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00