Orofacial granulomatosis in pediatric Crohn’s disease: clinical outcomes and genetic background in the era of biologics: a retrospective study in Japan
Clinical features of OFG associated with pediatric CD are diverse, and biologic agents were beneficial for OFG patients. NCF1 p.Arg90His mutation may contribute to the pathogenesis of pediatric CD complicating OFG.
Authors
- Toshiaki Shimizu (ORCID: https://orcid.org/0000-0003-0364-0022)
- Takuya Nishizawa
- Yugo Takaki (ORCID: https://orcid.org/0000-0002-3191-0192)
- Natsuki Ito (ORCID: https://orcid.org/0000-0002-6415-9753)
- Masao Nagasaki
- Yoichi Kakuta (ORCID: https://orcid.org/0000-0002-7042-009X)
- Takeo Naito (ORCID: https://orcid.org/0000-0002-9744-7946)
- K. Arai
- Ryusuke Nambu (ORCID: https://orcid.org/0000-0002-7206-7111)
- Junichi Hosokawa
- Tatsuki Mizuochi (ORCID: https://orcid.org/0000-0002-2943-7068)
- Yosuke Kawai
- Ichiro Takeuchi
- Takashi Ishige
- Itaru Iwama
- Shin-ichiro Hagiwara
- Mei Haruyama
- Takahiro Kudo
- Hirotaka Shimizu
Institutions
- Kurume University (JP)
- Kyushu University (JP)
- Gunma University (JP)
- Tohoku University (JP)
- Kyoto University (JP)
- Juntendo University (JP)
- Osaka Women's and Children's Hospital (JP)
- Saitama Children's Medical Center (JP)
- Japanese Red Cross Kumamoto Hospital (JP)
- National Center For Child Health and Development (JP)
- Kazusa DNA Research Institute (JP)
Publication Details
- Journal
- Intestinal Research
- Published
- 2025-12-22
- DOI
- https://doi.org/10.5217/ir.2025.00109
- Primary Topic
- Autoimmune and Inflammatory Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Ministry of Education, Culture, Sports, Science and Technology