Examining the Interaction of Alzheimer's Disease and TDP‐43 Neuropathology, and Clinical Diagnosis on Neuropsychiatric Symptoms Burden
The findings highlight the role of clinical diagnosis on NPS across domains, with AD and TDP-43 neuropathology and demographic factors exerting domain-specific effects, most notably in delusions and apathy. Interaction effects between neuropathology and clinical diagnosis were only seen in apathy, suggesting that pathology and clinical diagnosis may have independent effects on NPS. Future research is warranted to examine these effects longitudinally.
Authors
- Neda Rashidi‐Ranjbar (ORCID: https://orcid.org/0000-0002-2125-1090)
- Simon Graham (ORCID: https://orcid.org/0000-0002-2214-8212)
- Nathan W. Churchill (ORCID: https://orcid.org/0000-0001-8481-2505)
- Adrienne Lloyd Atayde
- Marc A. Khoury (ORCID: https://orcid.org/0000-0001-5863-6974)
- David G. Munoz (ORCID: https://orcid.org/0000-0001-6027-8870)
- Tom A. Schweizer
- Francis A Fernandes
- Corinne E. Fischer
- Luis R Fornazzari
Institutions
- St. Michael's Hospital (CA)
- University of Toronto (CA)
- Sunnybrook Hospital (CA)
- Sunnybrook Research Institute
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70857_103861
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00