Reducing Loneliness and Social Isolation Through the HELPeN Telephone-Call Program: Results from a Randomized Controlled Trial in Older Adults Living in the Community

<b>Background/Objectives:</b> Loneliness is a significant public health issue among older adults, especially in rural and socioeconomically vulnerable groups. Telephone-based interventions have become a scalable, cost-effective way to reduce social isolation, although evidence of their long-term effects on various health outcomes remains limited. This study aimed to assess how effective HELPeN, a structured telephone program delivered by trained nursing students, is in decreasing loneliness and enhancing psychosocial and cognitive health in community-living older adults. <b>Methods:</b> A randomized controlled trial was conducted with 119 older adults (≥65 years) residing in the community. Participants were allocated to either an intervention group (n = 65), which received weekly structured telephone calls over 9 months, or a control group (n = 54), which received standard care. Outcomes were evaluated at baseline (M0), mid-intervention (M1-M3), and 3 months after the intervention (M4). The primary outcomes measured included loneliness and perceived social support. Secondary outcomes comprised functional status, comorbidities, depressive symptoms, quality of life, sleep quality, and cognitive function. The data were analyzed using repeated-measures ANOVA with Greenhouse-Geisser correction. <b>Results:</b> Significant group interactions over time were identified for loneliness (F = 5.92, <i>p</i> = 0.001, η² = 0.067), social support (F = 3.39, <i>p</i> = 0.023, η² = 0.043), depressive symptoms (F = 3.87, <i>p</i> = 0.019, η² = 0.046), and cognitive status (F = 5.35, <i>p</i> = 0.002, η² = 0.063). No significant differences were found for functional status, comorbidity, sleep quality, or quality of life. <b>Conclusions:</b> The HELPeN program demonstrated significant effectiveness in reducing loneliness and social isolation, and in improving emotional, cognitive, and sleep-related outcomes in older adults. As a low-cost and scalable model, this intervention strengthens the role of nursing students in addressing social determinants of health and may be integrated into community and public health strategies targeting vulnerable aging populations.