Overexpression of the lncRNA TUG1 regulates high-glucose-induced endocytic clearance dysfunction in HLSECs via the Wnt/β-catenin signaling pathway
LncRNA TUG1 attenuates high glucose-induced endocytic clearance dysfunction in HLSECs, potentially via regulating the Wnt/β-catenin pathway. As a key regulatory target for HLSEC endocytic function, TUG1 offers novel perspectives for understanding MAFLD's pathogenesis and developing targeted therapies.
Authors
- Weiwen Ding
- Shuyue Wang
- Yingying Li
- Qianqian Tian
- Jing Ju
- Junyi Zhu
- Lirong Wei
- Qi Zhang
- Rangbao Cheng
Institutions
- Gansu University of Traditional Chinese Medicine (CN)
- Gansu Provincial Hospital (CN)
- Lanzhou University Second Hospital (CN)
- First Hospital of Lanzhou University (CN)
- Lanzhou University (CN)
Publication Details
- Journal
- European journal of medical research
- Published
- 2025-12-26
- DOI
- https://doi.org/10.1186/s40001-025-03722-w
- Primary Topic
- Cellular transport and secretion
- Type
- article
- Field-Weighted Citation Impact
- 0.00