APC loss promotes endometrial cancer progression by upregulating FGF12 expression: A integrated multi-omics analysis
Loss of APC promotes EC cell migration and reprograms chromatin architecture to upregulate FGF12, activating tumorigenesis-related protein kinase B (AKT) and mitogen-activated protein kinase (MAPK) signaling pathways and driving EC progression. Elevated FGF12 levels are associated with poor prognosis, highlighting its potential as a therapeutic target for EC patients with low APC expression.
Authors
- Yunfeng Song
- Yiding Bian (ORCID: https://orcid.org/0000-0003-1558-3918)
- Yiran Li (ORCID: https://orcid.org/0000-0002-4658-3876)
- Cheng Zhong (ORCID: https://orcid.org/0000-0002-5422-3766)
- Xiang Hu
- Qizhi He
- Wen Shuai
- Jian Huang
Institutions
- Shanghai First Maternity and Infant Hospital (CN)
Publication Details
- Journal
- Chinese Medical Journal
- Published
- 2025-12-25
- DOI
- https://doi.org/10.1097/cm9.0000000000003591
- Primary Topic
- Fibroblast Growth Factor Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00