A cerebrospinal fluid synaptic protein biomarker for prediction of cognitive resilience versus decline in Alzheimer's disease
Overall, our findings underscore CSF YWHAG:NPTX2 and the corresponding plasma signature as robust prognostic biomarkers for AD onset and progression beyond gold-standard biomarkers of Aβ, tau, and neurodegeneration and implicate synapse dysfunction as a core driver of AD dementia.
Authors
- Yann Le Guen (ORCID: https://orcid.org/0000-0001-6649-8364)
- Amelia Farinas (ORCID: https://orcid.org/0000-0002-6697-8883)
- Beth A. Stevens (ORCID: https://orcid.org/0000-0003-4226-1201)
- Anthony D. Wagner (ORCID: https://orcid.org/0000-0003-0624-4543)
- Daniel Western (ORCID: https://orcid.org/0000-0003-3725-9553)
- Jingsha Chen
- Chengran Yang (ORCID: https://orcid.org/0000-0003-4577-5590)
- Tuomas Rauramaa (ORCID: https://orcid.org/0000-0002-2250-327X)
- Ville Leinonen (ORCID: https://orcid.org/0000-0002-4282-4687)
- Lena Karlsson (ORCID: https://orcid.org/0000-0003-2749-7195)
- Hamilton Se‐Hwee Oh (ORCID: https://orcid.org/0000-0001-8192-7593)
- Michael R. Duggan (ORCID: https://orcid.org/0000-0002-1029-4423)
- Kathleen L. Poston (ORCID: https://orcid.org/0000-0003-3424-7143)
- Ian H. Guldner (ORCID: https://orcid.org/0000-0001-8715-136X)
- Divya Channappa
- Nader Morshed (ORCID: https://orcid.org/0000-0002-0346-9651)
- Sanna‐Kaisa Herukka (ORCID: https://orcid.org/0000-0003-3308-8662)
- Deniz Yagmur Urey
- Keenan A. Walker (ORCID: https://orcid.org/0000-0002-5989-9853)
- Alexandra N. Trelle (ORCID: https://orcid.org/0000-0003-2837-8753)
- Elizabeth C. Mormino (ORCID: https://orcid.org/0000-0002-4542-6537)
- Nicolai Franzmeier (ORCID: https://orcid.org/0000-0001-9736-2283)
- Alexander J. Ehrenberg (ORCID: https://orcid.org/0000-0003-4334-9424)
- Oskar H. Hansson
- Antti Johannes Luikku (ORCID: https://orcid.org/0000-0003-2864-1953)
- Jigyasha Timsina (ORCID: https://orcid.org/0000-0003-4794-9187)
- Zeyu Zhu
- Ted N. Wilson
- Anssi Lipponen
- Tony Wyss‐Coray
- Muhammad Ali
- Mikko Hiltunen
- Carlos Cruchaga
- Yuanyuan Shen
- Rebecca F. Gottesman
- Henrik Zetterberg
- David A. A. Bennett
- Josef Coresh
Institutions
- Broad Institute (US)
- Boston Children's Hospital (US)
- Johns Hopkins University (US)
- University of Eastern Finland (FI)
- University of California, San Francisco (US)
- Neurosciences Institute (US)
- Lund University (SE)
- Washington University in St. Louis (US)
- Hong Kong Science and Technology Parks Corporation (HK)
- LMU Klinikum (DE)
- Kuopio University Hospital (FI)
- Innovative Genomics Institute (US)
- National Institute of Neurological Disorders and Stroke (US)
- Munich Cluster for Systems Neurology (DE)
- UK Dementia Research Institute (GB)
- National Institute on Aging (US)
- Skåne University Hospital (SE)
- The London College (GB)
- University College London (GB)
- Rush University (US)
- New York University (US)
- Ludwig-Maximilians-Universität München (DE)
- University of Gothenburg (SE)
- University of California, Berkeley (US)
- Stanford University (US)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_102349
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00