Non‐amnesic preclinical traits in autosomal dominant Alzheimer's disease: Executive functions in <i>APP</i> <sub>V717I</sub> Mexican carriers
While memory problems are frequently reported in preclinical carriers of other ADAD mutations, our PC- APP<sub>V717I</sub> and NC groups scored similarly on memory tasks. However, we found preclinical difficulties in the MWCST, which assesses cognitive flexibility. YoS is positively correlated and predicts this result. To our knowledge, no published studies report preclinical EF performance in any of the APP mutations, so our work marks a precedent in exploring EF in APPV717I through this stage, being this the most frequently identified APP mutation worldwide.
Authors
- Esmeralda Matute (ORCID: https://orcid.org/0000-0003-0118-9960)
- Angélica Zuno‐Reyes
- John M. Ringman (ORCID: https://orcid.org/0000-0001-5429-0777)
- Sofía Dumois‐Petersen (ORCID: https://orcid.org/0009-0003-5858-8978)
- Ricardo Jauregui Torres
- Figuera Luis E.
- Karina Pérez‐Rubio
Institutions
- University of Southern California (US)
- Mexican Social Security Institute (MX)
- Universidad de Guadalajara (MX)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70857_105651
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00